TRIMIPRAMINE MALEATE

Trimipramine Maleate 25mg, Oral capsule

Marijuana

· Severity: Major

· Notes for Consumers: Combining marijuana with this medicine may increase blood pressure or heart rate. It can also increase nervousness or troubles with sleep. Contact your health care provider right away if you develop a fast or irregular heartbeat, a severe headache, or other new or unusual side effects.

· Notes for Professionals: Avoid concurrent use of marijuana and tricyclic antidepressants as use may result in adverse cardiovascular effects, such as tachycardia and cardiac arrhythmias. Marijuana is known to produce significant increases in heart rate and cardiac output lasting for 2 to 3 hours. Further, rare case reports of myocardial infarction and cardiac arrhythmias have been associated with marijuana use. Tricyclic antidepressants have also been reported to produce a wide range of cardiovascular effects including cardiac arrhythmias, palpitations, hypertension, ventricular tachycardia, heart failure, and stroke. Coadministration of marijuana with tricyclic antidepressants may result in significant cardiovascular adverse events and thus, should be avoided.

Trimipramine Maleate 25mg, Oral capsule

Tobacco

· Severity: Moderate

· Notes for Consumers: Tobacco smoking may reduce the effectiveness of this drug in treating your condition. The smoke contains substances that speed the removal of this drug from the body. If you take this drug and are trying to quit smoking, you may experience increased drug-related side effects like drowsiness, constipation, dizziness, difficulty with urination, dry mouth and eyes or confusion if you stop smoking. Make sure your prescriber is aware if you smoke or if you are trying to quit smoking.

· Notes for Professionals: Physiological changes resulting from tobacco smoking cessation, with or without nicotine replacement, may alter the pharmacokinetics of certain concomitant medications, such as tricyclic antidepressants (TCAs). Doses of TCAs may need to be adjusted in patients who successfully quit smoking. Tobacco smoking has been shown to increase the clearance of TCAs by inducing hepatic microsomal enzymes, likely due to the hydrocarbons of tobacco smoke. Sudden smoking cessation may result in a reduced clearance of TCAs, despite the initiation of nicotine replacement products.

Trimipramine Maleate 25mg, Oral capsule

Alcohol

· Severity: Moderate

· Notes for Consumers: It is recommended that you limit or avoid Alcoholic drinks while you are taking this medication. Alcohol can affect the mood and interfere with the drug treatment, and may increase the risk of side effects, such as sedation and dizziness. Do not drive or operate machinery if you are drinking alcohol-containing beverages.

· Notes for Professionals: Patients should be cautioned about using alcohol concurrently, since tricyclic antidepressants (TCAs) may exaggerate the CNS depressant response to alcohol, leading to an increase in sedation or psychomotor impairment. In some studies, alcohol has increased the unbound form of the TCA in the blood, which might be related to exagerrated clinical effect.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>