Temsirolimus Food, Alcohol, Supplements and Drug Interactions

TEMSIROLIMUS (Generic for TORISEL)

QTY 1 • FDN 30MG/3 • VIAL • Near 77381

TEMSIROLIMUS/Torisel (TEM sir OH li mus) is a drug that alters immune system response in the body. It is used to treat renal cell cancer.

TEMSIROLIMUS (Generic for TORISEL) Lifestyle Interactions

Temsirolimus 25mg/1mL, Solution for injection

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Temsirolimus with Grapefruit Juice. Grapefruit Juice may increase the levels of Temsirolimus in your body and side effects from Temsirolimus may be worse.

· Notes for Professionals: Avoid consumption of grapefruit or grapefruit juice with temsirolimus due to increased plasma concentrations of the primary active metabolite of temsirolimus (sirolimus). Temsirolimus is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor did not significantly affect temsirolimus exposure, but increased the AUC and Cmax of sirolimus by 3.1-fold and 2.2-fold, respectively.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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Prescription prices may vary from pharmacy to pharmacy and are subject to change. The pricing estimates given are based on the most recent information available and may change based on when you actually fill your prescription at the pharmacy.

DISCOUNT ONLY - NOT INSURANCE. Discounts are available exclusively through participating pharmacies. The range of the discounts will vary depending on the type of prescription and the pharmacy chosen. This program does not make payments directly to pharmacies. Members are required to pay for all prescription purchases. Cannot be used in conjunction with insurance. You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. This program is administered by Medical Security Card Company, LLC, Tucson, AZ.

*Average and up to savings percentages are based on all discounted prescriptions that were run through the WellRx program in 2022. Discount percentages represent savings provided off of pharmacies’ retail prices for consumers who do not have a discount program and pay cash.

The day supply is based upon the average dispensing patterns for the specific drug and strength. The Program, as well as the prices and the list of covered drugs, can be modified at any time without notice.

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