TASIMELTEON (Generic for HETLIOZ)

Tasimelteon 20mg, Oral capsule

Tobacco

· Severity: Major

· Notes for Consumers: Tasimelteon may not work as well in treating your condition if you smoke Tobacco products. Talk to your healthcare provider if you are a smoker or change your smoking habits while taking Tasimelteon. If you stop smoking tobacco you may need to watch for an increase in tasimelteon side-effects, like headache, increased drowsiness, or changes in moods or behaviors. Report any unusual side effects to your health care professional.

· Notes for Professionals: Due to partial metabolism of tasimelteon by CYP1A2, drug exposure is decreased by about 40% in smokers compared to non-smokers. Patients should be advised of the potential for reduced efficacy due to tobacco use.

Tasimelteon 20mg, Oral capsule

Alcohol

· Severity: Major

· Notes for Consumers: Avoid alcoholic drinks while you are taking Tasimelteon. Using Tasimelteon with alcohol can lead to serious side effects. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

· Notes for Professionals: A single dose study indicated a trend towards additive effects of tasimelteon and alcohol on some psychomotor tests. Patients should be cautioned about the potential adverse effects of ethanol ingestion during treatment with tasimelteon.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>