TALZENNA

Talazoparib 1mg, Oral capsule

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Do not take Talazoparib and Grapefruit Juice together without talking to your health care provider. Side effects from Talazoparib may get worse if you take Grapefruit Juice or grapefruit-containing foods. Contact your health care provider if you experience nausea, vomiting, diarrhea, signs of infection including fever or chills, cough, sore throat, pain or trouble passing urine, unusual bruising or bleeding, dark yellow or brown urine, general ill feeling or flu-like symptoms, light-colored stools, loss of appetite, right upper belly pain, unusually weak or tired, or yellowing of the eyes or skin.

· Notes for Professionals: Advise patients to avoid grapefruit juice while taking talazoparib due to increased talazoparib exposure. Talazoparib is a P-glycoprotein (P-gp) substrate and grapefruit juice is a P-gp inhibitor. Coadministration with other P-gp inhibitors increased talazoparib exposure by 8% to 45%.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>