SILODOSIN (Generic for RAPAFLO)

Silodosin 8mg, Oral capsule

Alcohol

· Severity: Moderate

· Notes for Consumers: Use caution when combining silodosin with alcohol-containing beverages. Alcohol-containing beverages may increase the effects of silodosin, which may lower the blood pressure. If the blood pressure drops too low, you may become dizzy or feel faint. To limit this interaction, avoid or limit alcohol-containing beverages while taking silodosin. Do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away.

· Notes for Professionals: Use caution when combining silodosin with alcohol-containing beverages. Alcohol-containing beverages may increase the effects of silodosin, which may lower the blood pressure. Silodosin ordinarily does not have much effect on blood pressure and the manufacturer does not make any formal advice on alcohol use, However, published literature suggests that ethanol potentiates antihypertensive effects of alpha blockers, including selective ones like silodosin. Some experts advise that the patient to limit alcohol use while using this drug.

Silodosin 8mg, Oral capsule

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Grapefruit juice may increase the actions of Silodosin and potentially increase its side effects. If your blood pressure drops too low while taking Silodosin, you may become dizzy or feel faint. To limit this interaction, do not stand or sit up too quickly. You should also limit or avoid grapefruit juice while taking Silodosin. Contact your prescriber if you have dizziness or other side effects that do not go away.

· Notes for Professionals: Silodosin is extensively metabolized by hepatic cytochrome P450 3A4. Grapefruit juice contains compounds that inhibit the activity of P-450 enzymes in cells lining the intestinal wall. In theory, grapefruit juice may cause significant increases in silodosin plasma concentrations.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>