RIVASTIGMINE (Generic for EXELON)

Rivastigmine Tartrate 1.5mg, Oral capsule

Tobacco

· Severity: Moderate

· Notes for Consumers: Nicotine may decrease the effectiveness of rivastigmine. If you smoke or use nicotine, notify your prescriber if you experience a worsening of your symptoms that may indicate that your drug is not working as well for you. If you suddenly stop smoking, this may increase the actions or side effects of rivastigmine; notify your prescriber if you notice increased drowsiness, dizziness, nausea, vomiting, diarrhea, or other unusual side effects.

· Notes for Professionals: Tobacco smoking (i.e., nicotine) has been shown to increase the oral clearance of rivastigmine by 23% versus patients who are non-smokers. Tobacco smoke contains polycyclic aromatic hydrocarbons that induce hepatic CYP450 microsomal enzymes (e.g., CYP1A1, CYP1A2, CYP2E1); however, rivastigmine is not metabolized by the CYP450 isoenzymes. Thus, the mechanism and clinical significance of this potential interaction are not clear. The sudden cessation of tobacco smoking may result in a reduced clearance of rivastigmine, despite the initiation of a nicotine replacement product.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>