PENTAZOCINE-NALOXONE HCL

Naloxone Hydrochloride 0.5mg, Pentazocine Hydrochloride 50mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Avoid alcohol-containing drinks while taking this medicine. Using this drug along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how this drug affects you, and especially if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

· Notes for Professionals: Alcohol is associated with CNS depression. The combined use of alcohol and CNS depressants can lead to additive CNS depression, which could be dangerous in tasks requiring mental alertness and fatal in overdose. Alcohol taken with other CNS depressants can lead to additive respiratory depression, hypotension, profound sedation, or coma. Consider the patient's use of alcohol or illicit drugs when prescribing CNS depressant medications. In many cases, the patient should receive a lower dose of the CNS depressant initially if the patient is not likely to be compliant with avoiding alcohol.

Naloxone Hydrochloride 0.5mg, Pentazocine Hydrochloride 50mg, Oral tablet

Tobacco

· Severity: Moderate

· Notes for Consumers: Tobacco smoking may reduce the effectiveness of Pentazocine at treating pain, by speeding the removal of the drug from the body. Alternatively, if you take Pentazocine and suddenly stop smoking, you may feel drowsy or more tired, and should not drive or operate machinery until you know how Pentazocine affects you. If you notice slurred speech, confusion, severe weakness, or difficulty breathing while taking Pentazocine, contact your health care provider immediately.

· Notes for Professionals: Tobacco smoking is associated with increased hepatic metabolism of pentazocine; reduced analgesia with pentazocine has been reported in cigarette smokers. Conversely, sudden smoking cessation may cause an increase in the therapeutic effects of pentazocine as hepatic enzyme activities return to normal, despite the use of nicotine replacement products.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>