Multaq Food, Alcohol, Supplements and Drug Interactions

MULTAQ

QTY 60 • 400 MG • Tablet • Near 77381

DRONEDARONE (droe NE da rone) treats a fast or irregular heartbeat (arrhythmia). It works by slowing down overactive electric signals in the heart, which stabilizes your heart rhythm. It belongs to a group of medications called antiarrhythmics.

MULTAQ Lifestyle Interactions

Dronedarone 400mg, Oral tablet

Marijuana

· Severity: Moderate

· Notes for Consumers: The effects of marijuana may be increased and side effects may get worse if it is combined with this medicine. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice slurred speech, confusion, severe drowsiness, increased heart rate, or any other new or unusual side effects.

· Notes for Professionals: The incidence of marijuana associated adverse effects may change following coadministration with dronedarone. Dronedarone is an inhibitor of CYP3A4, an isoenzyme partially responsible for the metabolism of marijuana's most psychoactive compound, delta-9-tetrahydrocannabinol (Delta-9-THC). When given concurrently with dronedarone, the amount of Delta-9-THC converted to the active metabolite 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) may be reduced. These changes in Delta-9-THC and 11-OH-THC plasma concentrations may result in an altered marijuana adverse event profile.

Dronedarone 400mg, Oral tablet

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Consuming grapefruit juice can increase the side effects of Dronedarone. Contact your prescriber immediately if you experience unexplained muscle aches, muscle pain or tenderness, general weakness or fatigue, side or back pain, or decreased urination while taking Dronedarone.

· Notes for Professionals: Concomitant use of dronedarone and grapefruit juice should be avoided. Dronedarone is metabolized by CYP3A. Grapefruit juice is a moderate inhibitor of CYP3A4. The concomitant administration of dronedarone and grapefruit juice results in an increase in dronedarone exposure by 3-fold and increase in dronedarone Cmax of 2.5-fold. No data exist regarding the appropriate dose adjustment needed to allow safe administration of dronedarone and grapefruit juice.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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Prescription prices may vary from pharmacy to pharmacy and are subject to change. The pricing estimates given are based on the most recent information available and may change based on when you actually fill your prescription at the pharmacy.

DISCOUNT ONLY - NOT INSURANCE. Discounts are available exclusively through participating pharmacies. The range of the discounts will vary depending on the type of prescription and the pharmacy chosen. This program does not make payments directly to pharmacies. Members are required to pay for all prescription purchases. Cannot be used in conjunction with insurance. You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. This program is administered by Medical Security Card Company, LLC, Tucson, AZ.

*Average and up to savings percentages are based on all discounted prescriptions that were run through the WellRx program in 2022. Discount percentages represent savings provided off of pharmacies’ retail prices for consumers who do not have a discount program and pay cash.

The day supply is based upon the average dispensing patterns for the specific drug and strength. The Program, as well as the prices and the list of covered drugs, can be modified at any time without notice.

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