KISQALI

Ribociclib 200mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take ribociclib with grapefruit or grapefruit juice. Taking these together may increase ribociclib levels and ribociclib side effects.

· Notes for Professionals: Avoid the concomitant use of ribociclib and grapefruit or grapefruit juice; the systemic exposure of ribociclib may be increased resulting in an increase in ribociclib-related adverse reactions. Ribociclib is a CYP3A4 substrate and grapefruit is a strong CYP3A inhibitor. Coadministration with another strong CYP3A4 inhibitor increased the ribociclib AUC and Cmax values by 3.2-fold and 1.7-fold, respectively, in healthy volunteers.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>