ISTURISA

Osilodrostat 1mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Grapefruit juice or grapefruit-containing foods and Osilodrostat together without talking to your health care professional. Side effects may get worse if you drink Grapefruit juice or consume grapefruit-containing foods while taking Osilodrostat. Contact your health care provider if you experience nausea, vomiting, loss of appetite, abdominal pain, dizziness, extreme tiredness, or other unusual effects.

· Notes for Professionals: Advise patients to avoid grapefruit juice or grapefruit-containing foods while taking osilodrostat; concurrent use may increase osilodrostat exposure and the risk of osilodrostat-related adverse reactions. Osilodrostat is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>