ISRADIPINE

Isradipine 2.5mg, Oral capsule

Grapefruit juice

· Severity: Major

· Notes for Consumers: Grapefruit juice and grapefruit-containing foods may increase the effects of Isradipine. Do not significantly increase grapefruit juice intake while taking this drug, or avoid grapefruit juice if possible. If the blood pressure drops too low while taking this medicine, you may become dizzy or feel faint; do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away while taking this medicine. If you notice new or increased swelling of your legs or ankles, tell your health care provider.

· Notes for Professionals: Grapefruit juice contains compounds that inhibit the cytochrome P-450 CYP3A4 isozyme in the gut wall. Although data are not available for isradipine, grapefruit juice can increase the serum concentrations and oral bioavailability of most calcium-channel blockers. It is generally recommended to avoid grapefruit juice ingestion during calcium-channel blocker therapy.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>