IMBRUVICA

Ibrutinib 140mg, Oral capsule

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Ibrutinib with grapefruit, grapefruit juice, or Seville oranges. Taking these together may increase Ibrutinib side effects that might be increased include diarrhea, musculoskeletal pain, rash, nausea, bruising or bleeding, fatigue, and fever or infection.

· Notes for Professionals: Advise patients to avoid the concomitant use of ibrutinib and grapefruit, grapefruit juice, or Seville oranges during ibrutinib therapy. ibrutinib expsoure may increase resulting in severe ibrutinib toxicity (e.g., hematologic toxicity, bleeding, infection). Ibrutinib is a CYP3A4 substrate; grapefruit and Seville oranges are strong and/or moderate CYP3A4 inhibitors. When ibrutinib was administered with multiple doses of strong CYP3A4 inhibitors, the Cmax and AUC values of ibrutinib were increased significantly.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>