IBUPROFEN-FAMOTIDINE (Generic for DUEXIS)

Ibuprofen 800mg, Famotidine 26.6mg, Oral tablet

Marijuana

· Severity: Moderate

· Notes for Consumers: The effects of marijuana may be decreased if combined with this medicine. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice slurred speech, confusion, severe drowsiness, increased heart rate, or any other new or unusual side effects.

· Notes for Professionals: Administering nonsteroidal antiinflammatory drugs (NSAIDs) concurrently with marijuana may limit some of marijuana's pharmacologic activities. Certain actions of marijuana require prostaglandin-mediated processes to occur; NSAIDs may interfere with these processes thereby decreasing marijuana's effect. Coadministration of indomethacin with marijuana has been shown to significantly decrease euphoria, tachycardia, and the intraocular pressure lowering activity of marijuana.

Ibuprofen 800mg, Famotidine 26.6mg, Oral tablet

Alcohol

· Severity: Mild

· Notes for Consumers: Side effects from drinking alcohol-containing drinks may get worse if you take H2-blockers such as cimetidine, famotidine, nizatidine, and ranitidine. Avoid or minimize your intake of alcohol-containing drinks while taking H2-blockers.

· Notes for Professionals: Some studies have suggested that H2-receptor antagonists inhibit gastric alcohol (ethanol) dehydrogenase and thus decrease the first pass metabolism of ethanol, and some studies have suggested an interaction may not always occur. A meta-analysis evaluating the effects of H2-blockers on blood ethanol concentrations reported that only cimetidine and ranitidine, but not other H2-blockers, caused small elevations in serum ethanol levels. However, it was reported that larger studies were less likely to show an effect and that these elevations were not likely to be clinically relevant.

Ibuprofen 800mg, Famotidine 26.6mg, Oral tablet

Tobacco

· Severity: Moderate

· Notes for Consumers: Tobacco-smoking may increase the risk for ulcers and gastrointestinal problems with these drugs. Ask your health care provider about a plan to stop smoking. If you have persistent stomach upset, vomit blood or what looks like coffee grounds, or have black, tarry stools, contact your health care provider immediately.

· Notes for Professionals: Concomitant use of nonsteroidal antiinflammatory drugs (NSAIDs) with tobacco smoking may enhance the risk of gastrointestinal (GI) side effects. Tobacco smoking may independently increase the risk of peptic ulcer and GI bleeding, and thus may increase the risk with NSAID usage. Patients using tobacco and NSAIDs concurrently should be monitored closely for GI adverse reactions.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>