Epidiolex Food, Alcohol, Supplements and Drug Interactions

EPIDIOLEX

QTY 20 • 100 MG/ML • Solution • Near 77381

CANNABIDIOL (kan a bi DYE ol) prevents and controls seizures in people with epilepsy. It works by calming overactive nerves in your body.

EPIDIOLEX Lifestyle Interactions

Cannabidiol 100mg/1mL, Oral solution

Alcohol

· Severity: Moderate

· Notes for Consumers: Avoid alcohol-containing drinks while taking Cannabidiol. Side effects from Cannabidiol may get worse if you drink alcohol-containing drinks. You may feel drowsy or more tired when taking this drug with alcohol. Do not drive or operate machinery. If you notice confusion, dizziness, extreme sleepiness, lightheadedness, slurred speech, severe weakness, or difficulty breathing, contact your health care provider immediately.

· Notes for Professionals: Monitor for excessive sedation and somnolence during coadministration of cannabidiol and alcohol. CNS depressants can potentiate the effects of cannabidiol. Also, coadministration of cannabidiol with alcohol increased exposure to cannabidiol, with 93% increased Cmax and 63% greater AUC.

Cannabidiol 100mg/1mL, Oral solution

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: You may experience more Caffeine-related side effects or a decreased effect of Caffeine while taking Cannabidiol. Too much Caffeine can cause nausea, nervousness, sleeplessness, or tremor. You may need to limit your Caffeine intake. Common foods and beverages containing caffeine include coffee, teas, colas and chocolate. Many non-prescription drugs and diet aids may also contain caffeine.

· Notes for Professionals: Coadministration of cannabidiol and caffeine-containing foods/beverages may alter plasma concentrations of caffeine resulting in an increased risk of adverse reactions and/or decreased efficacy. Caffeine is a substrate of CYP1A2; cannabidiol may inhibit and/or induce CYP1A2 at clinically relevant concentrations.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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Prescription prices may vary from pharmacy to pharmacy and are subject to change. The pricing estimates given are based on the most recent information available and may change based on when you actually fill your prescription at the pharmacy.

DISCOUNT ONLY - NOT INSURANCE. Discounts are available exclusively through participating pharmacies. The range of the discounts will vary depending on the type of prescription and the pharmacy chosen. This program does not make payments directly to pharmacies. Members are required to pay for all prescription purchases. Cannot be used in conjunction with insurance. You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. This program is administered by Medical Security Card Company, LLC, Tucson, AZ.

*Average and up to savings percentages are based on all discounted prescriptions that were run through the WellRx program in 2022. Discount percentages represent savings provided off of pharmacies’ retail prices for consumers who do not have a discount program and pay cash.

The day supply is based upon the average dispensing patterns for the specific drug and strength. The Program, as well as the prices and the list of covered drugs, can be modified at any time without notice.

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