DOXAZOSIN MESYLATE (Generic for CARDURA)

Doxazosin Mesylate 4mg, Oral tablet

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Although an interaction is possible, these drugs may be used together. Side effects of Doxazosin may get worse. If the blood pressure drops too low while taking these medications, you may become dizzy or feel faint. To limit this interaction, do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away.

· Notes for Professionals: Monitor blood pressure and for signs of hypotension during coadministration. The plasma concentrations of doxazosin may be elevated when administered concurrently with grapefruit juice. Grapefruit juice is a strong CYP3A4 inhibitor; doxazosin is a CYP3A4 substrate. Coadministration of doxazosin with a moderate CYP3A4 inhibitor resulted in a 10% increase in mean AUC and an insignificant increase in mean Cmax and mean half-life of doxazosin. Although not studied in combination with doxazosin, strong CYP3A4 inhibitors may have a larger impact on doxazosin concentrations and therefore should be used with caution.

Doxazosin Mesylate 4mg, Oral tablet

Alcohol

· Severity: Moderate

· Notes for Consumers: Talk to your doctor or healthcare professional before drinking alcoholic beverages while taking this medicine. Alcohol may increase dizziness or drowsiness, which may increase the risk for fainting, falls, or injury. Limit alcohol use whenever possible. Dizziness, lightheadedness may occur, especially when standing up from a lying or sitting position. Getting up slowly may help lessen the problem. Do not drive or operate machinery, or perform other potentially hazardous tasks, until the effects of this drug are known.

· Notes for Professionals: Some experts and manufacturers advise that the patient to limit alcohol use while using alpha-blockers. Alcohol-containing beverages may increase the effects of alpha-blockers, which may lower the blood pressure.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>