DONNATAL (Brand for PHENOBARBITAL-HYOSC-ATROP-SCOP)

Atropine Sulfate 0.0194mg, Hyoscyamine Sulfate 0.1037mg, Phenobarbital 16.2mg, Scopolamine Hydrobromide 0.0065mg, Oral tablet

Marijuana

· Severity: Major

· Notes for Consumers: Combining marijuana with this medicine may increase blood pressure or heart rate. It can also increase nervousness or troubles with sleep. Contact your health care provider right away if you develop a fast or irregular heartbeat, a severe headache, or other new or unusual side effects.

· Notes for Professionals: Avoid administering marijuana and atropine together as concurrent use may result in adverse cardiovascular effects, such as tachycardia and cardiac arrhythmias. Marijuana is known to produce significant increases in heart rate and cardiac output lasting for 2-3 hours. Further, rare case reports of myocardial infarction and cardiac arrhythmias have been associated with marijuana use. Atropine has also been reported to produce a wide range of cardiovascular effects including asystole, atrial fibrillation, premature ventricular contractions (PVCs), ventricular fibrillation, palpitations, and sinus tachycardia. Coadministration of marijuana with atropine may result in significant cardiovascular adverse events and thus, should be avoided.

Atropine Sulfate 0.0194mg, Hyoscyamine Sulfate 0.1037mg, Phenobarbital 16.2mg, Scopolamine Hydrobromide 0.0065mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Avoid alcohol-containing drinks while taking this medicine. Using this drug along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how this drug affects you, and especially if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

· Notes for Professionals: Alcohol is associated with CNS depression. The combined use of alcohol and CNS depressants can lead to additive CNS depression, which could be dangerous in tasks requiring mental alertness and fatal in overdose. Alcohol taken with other CNS depressants can lead to additive respiratory depression, hypotension, profound sedation, or coma. Consider the patient's use of alcohol or illicit drugs when prescribing CNS depressant medications. In many cases, the patient should receive a lower dose of the CNS depressant initially if the patient is not likely to be compliant with avoiding alcohol.

Atropine Sulfate 0.0194mg, Hyoscyamine Sulfate 0.1037mg, Phenobarbital 16.2mg, Scopolamine Hydrobromide 0.0065mg, Oral tablet

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: Caffeine may cause sleeplessness, so if you are taking a Barbiturate to help you sleep, you may wish to avoid taking caffeine and caffeine-containing foods like colas, coffee, teas, or chocolates within several hours prior to bedtime. Barbiturates may also decrease the actions of Caffeine; if you have a high intake of caffeinated foods or beverages you may experience a headache or irritability from decreased caffeine levels while taking these drugs until your body adjusts. If you take Caffeine for other purposes, notify your health care provider if you think Caffeine is not working as well for you.

· Notes for Professionals: Caffeine has been reported to increase the metabolism of barbiturates, and barbiturates increase caffeine elimination. Higher caffeine doses may be needed after barbiturate administration.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>