CYCLOSET

Bromocriptine Mesylate 0.8mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take grapefruit juice with bromocriptine without approval from your prescriber. Side effects may get worse if you take grapefruit juice together with bromocriptine. Contact your healthcare provider if you experience new or worsening side effects including confusion, hallucination, loss of contact with reality, falling asleep during normal activities like driving, nausea, tiredness, dizziness, vomiting, and headache.

· Notes for Professionals: Patients should avoid the use of grapefruit juice when bromocriptine is used for treatment of diabetes, ensuring adequate washout before initiating bromocriptine. Use this combination with caution in patients receiving bromocriptine for other indications. Concurrent use may significantly increase bromocriptine concentrations. Bromocriptine is extensively metabolized in the liver via CYP3A4; grapefruit juice is a strong inhibitor of CYP3A4.

Bromocriptine Mesylate 0.8mg, Oral tablet

Tobacco

· Severity: Mild

· Notes for Consumers: Let your prescriber know if you are a smoker if you take bromocriptine. It is not quite clear if tobacco smoking or nicotine products used to stop smoking can interact with bromocriptine treatment. Contact your health care provider if you notice any changes in your blood pressure or other effects if you are a smoker or are taking any products to stop smoking and take bromocriptine.

· Notes for Professionals: Use caution during use of tobacco or other nicotine-containing products while taking bromocriptine. Concurrent use of vasoconstrictors, such as nicotine, may result in enhanced vasoconstriction from ergot-based medications. Published reports of interactions between bromocriptine, an ergot derivative, and tobacco smoking or nicotine are not available. Safety and efficacy of bromocriptine for helping patients with smoking cessation is under investigation, but safety of use with nicotine products concurrently or if the patient continues to smoke is not established.

Bromocriptine Mesylate 0.8mg, Oral tablet

Alcohol

· Severity: Moderate

· Notes for Consumers: In general, it is recommended that you limit Alcoholic drinks while you are taking Bromocriptine. Alcohol may increase the risk of side effects due to bromocriptine. Decreased alertness, dizziness, drowsiness, or low blood pressure may occur. Do not drive or operate machinery if you are drinking alcohol-containing beverages.

· Notes for Professionals: Alcohol may potentiate some of the side effects of bromocriptine, including hypotension and somnolence. Patients should be advised to limit alcohol and not to drive or engage in activities where impaired alertness may put themselves or others at risk of serious injury (e.g., operating machines) until the effects of bromocriptine are known.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>