BEXAROTENE (Generic for TARGRETIN)

Bexarotene 75mg, Oral capsule

Marijuana

· Severity: Moderate

· Notes for Consumers: The effects of marijuana may be decreased if combined with this medicine. Do not drive or operate machinery until you know how this combination will affect you. Contact your health care provider right away if you notice slurred speech, confusion, severe drowsiness, increased heart rate, or any other new or unusual side effects.

· Notes for Professionals: The incidence of marijuana associated adverse effects may change following coadministration with bexarotene. Bexarotene is an inducer of CYP3A4, an isoenzyme partially responsible for the metabolism of marijuana's most psychoactive compound, delta-9-tetrahydrocannabinol (Delta-9-THC). When given concurrently with bexarotene, the amount of Delta-9-THC converted to the active metabolite 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC) may be increased. These changes in Delta-9-THC and 11-OH-THC plasma concentrations may result in an altered marijuana adverse event profile.

Bexarotene 75mg, Oral capsule

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Side effects from oral Bexarotene may get worse if you take the capsules with grapefruit juice. Avoid drinking large amounts of grapefruit juice while taking Bexarotene capsules. If you notice new or worsening side effects such as dry skin, rash, decreased energy, or yellowing of skin or eyes, contact your health care provider. There is no interaction with topical Bexarotene gel.

· Notes for Professionals: Bexarotene is metabolized by cytochrome P450 3A4 and grapefruit juice may increase the serum concentrations of bexarotene by inhibiting the metabolism of bexarotene via CYP3A4.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>