BELSOMRA

Suvorexant 20mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Inform your doctor if you regularly drink grapefruit juice or eat grapefruit. Side effects from Suvorexant may get worse if you regularly drink grapefruit juice, such as slurred speech, confusion, excess drowsiness, severe weakness, or difficulty breathing. Your doctor may need to adjust the dose of your Suvorexant. Do not drive or operate machinery within 8 hours of taking Suvorexant.

· Notes for Professionals: Suvorexant is primarily metabolized by CYP3A, and the manufacturer recommends a dose reduction to 5 mg/day initially of suvorexant, with an increase to 10 mg/day if clinically warranted, during concurrent use with moderate CYP3A inhibitors. A dose reduction should be considered in patients who regularly consume grapefruit juice, a moderate CYP3A inhibitor with the potential to increase suvorexant exposure.

Suvorexant 20mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Avoid alcoholic drinks while you are taking Suvorexant. Using Suvorexant with alcohol can lead to serious side effects. Do not drive or operate machinery if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

· Notes for Professionals: Patients should be advised not to consume alcohol in combination with suvorexant because of additive effects. When suvorexant was co-administered with alcohol, additive psychomotor impairment was demonstrated. There was no alteration in the pharmacokinetics of suvorexant.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>