ATENOLOL-CHLORTHALIDONE (Generic for TENORETIC 100)

Atenolol 50mg, Chlorthalidone 25mg, Oral tablet

Marijuana

· Severity: Major

· Notes for Consumers: Marijuana can decrease the ability of this medicine to control your blood pressure and heart rate. You may need to monitor your blood pressure and heart rate more often to make sure they are well-controlled. If you check your own blood pressure at home and notice an increase in your blood pressure or heart rate, contact your health care provider.

· Notes for Professionals: Avoid administering marijuana and beta-blockers together as concurrent use may result in decreased beta-blocker efficacy. Marijuana is known to produce significant increases in heart rate and cardiac output lasting for 2-3 hours. Further, rare case reports of myocardial infarction and cardiac arrhythmias have been associated with marijuana use. These marijuana-induced cardiovascular effects may be detrimental to patients requiring treatment with beta-blockers; thus, coadministration of beta-blockers and marijuana should be avoided.

Atenolol 50mg, Chlorthalidone 25mg, Oral tablet

Alcohol

· Severity: Moderate

· Notes for Consumers: It is best to limit your intake of alcohol while taking this drug. Alcohol can increase the risk for low blood pressure and dizziness. If the blood pressure drops too low, you may feel dizzy or faint, in some cases falls or fainting may occur. Do not drive or operate machinery, or perform other hazardous tasks if you have been taking alcohol with this drug.

· Notes for Professionals: Patients should be cautioned that ingesting alcohol can increase the chance of low blood pressure and dizziness when taking a thiazide diuretic or the related drug, metolazone. Patients may wish to limit alcohol ingestion while taking one of these diuretics and should be monitored for signs or symptoms of hypotension, including postural hypotension and dizziness.

Atenolol 50mg, Chlorthalidone 25mg, Oral tablet

Food

· Severity: Moderate

· Notes for Consumers: Atenolol may be taken without regard to most food or meals. There is one small study that suggests taking atenolol with orange juice directly might moderately lower atenolol's effectiveness. More data are needed to confirm these results. Why this interaction might occur is not known at this time. Until more data are available, it may be advisable to not significantly alter your orange juice intake while taking atenolol.

· Notes for Professionals: Coadministration of oral atenolol with most foods/meals does not appear to be a problem despite a 20% reduction in bioavailability. Administration directly with orange juice might have a moderately significant effect by decreasing bioavailability and mean Cmax by roughly 40%. Data are from a small single dose study in healthy volunteers. It is not known if this potential interaction results in clinically significant effects on heart rate or blood pressure reduction in populations of interest.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>