TRAZODONE HCL

Trazodone Hydrochloride 150mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Trazodone and Grapefruit Juice or grapefruit-containing foods together without talking to your health care provider. Side effects from Trazodone may be increased which can increase the risk of a dangerous change in heartbeat or heart rhythm.

· Notes for Professionals: Advise patients to avoid coadministration of trazodone with grapefruit juice due to the potential for increased trazodone exposure and associated adverse effects including QT prolongation. Trazodone is a CYP3A4 substrate; grapefruit juice is a strong CYP3A4 inhibitor. Coadministration of other strong CYP3A4 inhibitors increased the exposure of trazodone compared to the use of trazodone alone.

Trazodone Hydrochloride 150mg, Oral tablet

Alcohol

· Severity: Moderate

· Notes for Consumers: Limit the use of or avoid alcohol-containing drinks while taking this medicine. Using this drug along with alcohol can lead to serious side effects. You may feel drowsy or more tired when taking these drugs together. Do not drive or operate machinery until you know how this drug affects you, and especially if you are drinking alcohol-containing beverages. If you notice slurred speech, confusion, severe weakness, or difficulty breathing, contact your health care provider immediately.

· Notes for Professionals: Trazodone may enhance the response to alcohol and other CNS depressants. Trazodone can have significant sedative effects. The patient should be cautioned accordingly. In some studies, alcohol did not significantly alter the pharmacodynamic response to trazodone, but other individuals may have different responses.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>